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As apoptotic cells accumulate and fail to be internalized by phagocytes, they undergo secondary necrotic death leading to the leakage of intracellular oxidative and inflammatory components, which then propagate more inflammation, oxidative stress, and death in neighboring cells (Figure 5) (173)

Viscardi, R.M., Ullsperger, S

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Ipamorelin requires injection, which is a barrier for some people